RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-34c
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
PCR; dual-luciferase reporter assay etc.
Target
NA
Pathway
VEGF SIGNALING PATHWAY
PubMed ID
Title
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function
Year
2012
Function
"Improved outcome in lna-antimiR-34-treated myocardial infarction (MI) and transverse aortic constriction (TAC) mice was accompanied by up-regulation of several direct miR-34 targets, including vascular endothelial growth factors, vinculin, protein o-fucosyltranferase 1, NOTCH1, and semaphorin 4b, silencing of the entire miR-35 family can protect the heart against pathological cardiac remodeling and improve function."